Hutchinson-Gilford Progeria Syndrome
Published:  August 29, 2005 by PNAS (Proceedings of National Academy of Sciences of the United States of America)

Full Version Available:  http://www.pnas.org/content/102/36/12879.full#sec-

Summarized Version Below:

Before Reading the study it is important to know: 
Farnesylation is to attach a farnesyl group to a protein. Therefore, farnesyltransferase inhibitors (FTIs) is an enzyme that does not allow farnesyl groups to attach to proteins. Remeber if the farnesyl group is attatched it will cause nuclear bebbling or mishappen nuclei which is what scientist believe causes the accelerated aging.

Purpose

        To inhibit farnesylation of Progerin and see how it affects the shape of the nucleus in Progerian(HGPS) cells.

Procedure

Picture

Results:

Picture
Picture
Notice: FTI treatment causes the reversion of the nuclear lobulations seen in Progerian cells

Conclusion of the Experiment:

   FTI treatment causes the reversion of the nuclear lobulations (mishapen nuclei)  seen in Progerian cells.